NACCADRC ADSP PHC dataset. The data is sourced from the file(s) NACC_ADSP_PHC_Neuropath_2024.csv.
Usage
data(phc_neuropath)Format
A data frame with 19808 rows and 34 variables:
- NACCID
Participant ID
- PHC_AgeDeath
Age at Death
- PHC_BRAINWT
Brain Weight in grams
- PHC_INT
Interval between last exam and death (months)
- PHC_PMI
Post-mortem interval (hours)
- PHC_AMY_THAL
Thal Phase (0 = None 1 = Phase 1 2 = Phase 2 3 = Phase 3 4 = Phase 4 5 = Phase 5 NA = Not available)
- PHC_AMY_A
A Score (0 = None 1 = Thal Phase 1 or 2 2 = Thal Phase 3 3 = Thal Phase 4 or 5 NA = Not available)
- PHC_AMY_CERAD
CERAD (0 = None 1 = Sparse/Possible 2 = Moderate/Probable 3 = Definite/Frequent NA = Not available)
- PHC_AMY_ANY
Any Amyloid Presence (0 = None 1 = Some Amyloid NA = Not available)
- PHC_BRAA
Braak Stage (0 = None 1 = BRAAK Stage I 2 = BRAAK Stage II 3 = BRAAK Stage III 4 = BRAAK Stage IV 5 = BRAAK Stage V 6 = BRAAK Stage VI NA = Not available)
- PHC_B_SCORE
B score (0 = None 1 = BRAAK Stage I-II 2 = BRAAK Stage III-IV 3 = BRAAK Stage V-VI NA = Not available)
- PHC_ADNC
ADNC severity score (0 = Not AD 1 = Low 2 = Intermediate 3 = High NA = Not available)
- PHC_REAG
NIA-REAGAN criteria for AD (0 = None 1 = Low Likelihood 2 = Intermediate Likelihood 3 = High Likelihood NA = Not available)
- PHC_LEWY_full
PD Braak Staging (0 = None 1 = Brainstem predom. 2 = Limbic/amygdala (transitional) 3 = Neocortical (diffuse) 4 = Olfactory bulb or Region unspecified NA = Not available)
- PHC_LEWY_grp
PD Braak (grouped) (0 = None 1 = Brainstem predom. 2 = Transitional, diffuse, olfactory bulb, or region unspecified NA = Not available)
- PHC_LEWY_ANY
PD Braak (dichotomous) (0 = None 1 = Brainstem, transitional, diffuse, olfactory bulb, or region unspecified NA = Not available)
- PHC_INFA
Infarcts and lacunes (0 = No 1 = Yes NA = Not available)
- PHC_HEMOR
Hemorrhages (0 = No 1 = Yes NA = Not available)
- PHC_MICR
Microinfarcts (0 = No 1 = Yes NA = Not available)
- PHC_WMRCAL
White matter rarifaction (cerebral arteriosclerotic leukoencephalopthy) (0 = No 1 = Yes NA = Not available)
- PHC_WMR
White matter rarifaction (0 = None 1 = Mild 2 = Moderate 3 = Severe NA = Not available)
- PHC_WBVD
Whole brain vascular disease (0 = No 1 = Yes NA = Not available)
- PHC_HS_L
Hippocampal sclerosis (with laterality) (0 = None 1 = Unilateral 2 = Bilateral 3 = Present, Location UK NA = Not available)
- PHC_HS_S
Hippocampal sclerosis (simplified) (0 = No 1 = Yes NA = Not available)
- PHC_TDP43
TDP Whole Brain (Presence) (0 = No 1 = Yes (positive in amygdala/ hippocampus/etorhinal/neocortex) NA = Not available/Positive in Brainstem or Spinal Cord)
- PHC_TDP_3
TDP - 3 Component (0 = None 1 = Amygdala 2 = Hippocampus or Etorhinal 3 = Neocortex NA = Not available)
- PHC_TDP_5
TDP Stage; Assumes that TDP progresses from brainstem>amygdala>hippocampus>inferior temporal cortex>neocortex (0 = None 1 = Brainstem/Spinal Cord 2 = Amygdala 3 = Hippocampus 4 = Entorhinal 5 = Neocortex NA = Not available)
- PHC_CVD_S
Cerebrovascular Disease (simplified) (0 = None 1 = Presence NA = Not available)
- PHC_CVD_ATH
Atherosclerosis (0 = None 1 = Mild 2 = Moderate 3 = Severe NA = Not available)
- PHC_CVD_ATH_ANY
Atherosclerosis (dichotomous) (0 = None 1 = Mild, Moderate, or Severe NA = Not available)
- PHC_CVD_ART
Arteriolosclerosis (0 = None 1 = Mild 2 = Moderate 3 = Severe NA = Not available)
- PHC_CVD_ART_ANY
Arteriolosclerosis (dichotomous) (0 = None 1 = Mild, Moderate, or Severe NA = Not available)
- PHC_CVD_CAA
Cerebral Amyloid Angiopathy (CAA) (0 = None 1 = Mild 2 = Moderate 3 = Severe NA = Not available)
- PHC_CVD_CAA_ANY
Cerebral Amyloid Angiopathy (CAA) (dichotomous) (0 = None 1 = Mild, Moderate, or Severe NA = Not available)
Examples
if (FALSE) { # \dontrun{
browseVignettes('NACCADRC')
} # }